Nakazono, A., Adachi, N*., Takahashi, H., Seki, T., Hamada, D., Ueyama,
T., Sakai, N. and Saito, N.,
Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCγ in spinocerebellar ataxia type 14
J. Biol. Chem., 293 (2018) 14758-14774
Miyahara, T., Adachi, N., Seki, T., Hide I., , Tanaka, S., Saito, N., Irifune,
M. and Sakai, N*.
Propofol induced diverse and subtype-specific translocation of PKC families,
J. Pharmacol. Sci. 137 (2018) 20-29.
Shirafuji, T*., Ueyama, T., Adachi, N., Yoshino, K. Sotomaru, Y., Uwada, J., Kaneoka, A., Ueda, T., Tanaka, S., Hide, I., Saito, N. and Sakai, N.
The Role of Cysteine String Protein Alpha (CSPα) Phosphorylation at Serine
10, and 34, by Protein Kinase Cγ for Presynaptic Maintenance.
J. Neurosci. 38 (2018) 278-290.
2017年
Shirafuji T*, Ueyama T, Tanaka S, Hide I, Saito N and Sakai N.
Validation of Anti-CSPα, SNAP25, Tyrosine Hydroxylase, Ubiquitin, Cleaved
Caspase 3, and pSer PKC Motif Antibodies for Utilization in Western Blotting.
Acta Histochem Cytochem. 50 (2017) 177-180.
Fujii, H*., Takahashi, T., Mukai, T., Tanak,a S., Hosomi, N., Maruyama,
H., Sakai, N., and Matsumoto, M. Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer's disease - Hyperphosphorylation and cleavage of 4- and 3-repeat tau. J Cereb Blood Flow Metab. 37 (2017) 2441-2457.
2016年
Katarao, K., Murakawa, S., Asano, M., Usuki, N., Yamamoto, H., Shirafuji, T., Tanaka, S., Hide, I. and Sakai, N*..
The development of screening methods to identify drugs to limit ER stress
using wild-type and mutant serotonin transporter. Acta Histochem.Cytochem. 49 (2016) 197-206 DOI:
10.1016/j.jtcme.2016.01.006
Nakatani, Y., Amano, T., Yamamoto, H., Sakai, N. Tsuji, M. and Takeda,
H*. Yokukansan enhances the proliferation of B65 neuroblastoma. J. Traditional Complement. Med. 7 (2016) 34-44 DOI:
10.1016/j.jtcme.2016.01.006
Kamigaki M, Hide I*, Yanase Y, Shiraki H, Harada K, Tanaka Y, Seki T, Shirafuji
T, Tanaka S, Hide M, Sakai N. The
Toll-like receptor 4-activated neuroprotective microglia subpopulation survives
via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling. Neurochem
Int. 2016 Feb;93:82-94. doi: 10.1016/j.neuint.2016.01.003. Epub 2016 Jan 21.
Miyagi T, Tanaka S*, Hide I, Shirafuji T, Sakai N. The
Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local
Activation of PKA in Cerebellar Granular Neurons. PLoS
One. 2016 Jan 22;11(1):e0147466. doi: 10.1371/journal.pone.0147466. eCollection
2016.
2015年
Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima
T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda
KI, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ,
Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta
A*. The
Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine
and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in
Genomic Association Study. Curr Mol Med. 2015;15(3):265-74.doi: 10.2174/1566524015666150330145722
Kikuchi
N, Irifune M, Shimizu Y, Yoshida K, Morita K, Kanematsu T, Morioka N, Nakata Y, Sakai N*. Selective blockade of
N-methyl-D-aspartate channels in combination with dopamine receptor antagonism
induces loss of the righting reflex in mice, but not immobility.
Psychopharmacology (Berl). 2015 Jan;232(1):39-46. doi:
10.1007/s00213-014-3634-y. Epub 2014 May 31.
Takahashi H*, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D,
Irie K, Hirai H, Sakai N, Saito
N.
Identification and characterization of PKCγ, a kinase associated with SCA14,
as an amyloidogenic protein.
Hum Mol Genet. 2015 Jan 15;24(2):525-39. doi: 10.1093/hmg/ddu472.
Epub 2014 Sep 12.
2014年
Tanaka S*, Miyagi T, Dohi E, Seki T, Hide I,
Sotomaru Y, Saeki Y, Antonio Chiocca E, Matsumoto M, Sakai N.
Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli. Neurobiol
Dis. 2014 Aug;68:215-27. doi: 10.1016/j.nbd.2014.04.007.
Epub 2014 Apr 24.
Shirafuji T, Ueyama T, Yoshino K, Takahashi
H, Adachi N, Ago Y, Koda K, Nashida T, Hiramatsu N, Matsuda T, Toda T, Sakai N,
Saito N*.
The role of Pak-interacting exchange factor-β phosphorylation at serines
340 and 583 by PKCγ in dopamine release. J
Neurosci. 2014 Jul 9;34(28):9268-80. doi:
10.1523/JNEUROSCI.4278-13.2014.
Yamamoto K, Seki T*, Yamamoto H, Adachi N, Tanaka
S, Hide I, Saito N, Sakai N.
Deregulation of the actin cytoskeleton and macropinocytosis in response
to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar
ataxia type 14.
Front Physiol. 2014 Apr 1;5:126. doi:
10.3389/fphys.2014.00126. eCollection 2014.
2013年
Ogawa K, Seki T, Onji T, Adachi N, Tanaka S, Hide I, Saito N, Sakai
N.Mutant γPKC that causes spinocerebellar ataxia type 14 upregulates Hsp70,
which protects cells from the mutant's cytotoxicity Biochem Biophys Res Commun. 2013 Oct 11;440(1):25-30.
doi: 10.1016/j.bbrc.2013.09.013. Epub 2013 Sep 8.
Taniguchi
T, Tanaka S, Ishii A, Watanabe
M, Fujitani N, Sugeo A, Gotoh S, Ohta T, Hiyoshi M, Matsuzaki H, Sakai N, Konishi H.A brain-specific Grb2-associated regulator of extracellular signal-regulated
kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2,
contributes to neurite outgrowth of neuroblastoma cells by regulating Erk
signaling J Biol
Chem. 2013 Oct 11;288(41):29934-42. doi:
10.1074/jbc.M113.492520. Epub 2013 Sep 3.
Ueyama
T, Son J, Kobayashi T, Hamada T, Nakamura T, Sakaguchi H, Shirafuji T, Saito N.Negative charges in the
flexible N-terminal domain of Rho GDP-dissociation inhibitors (RhoGDIs)
regulate the targeting of the RhoGDI-Rac1 complex to membranes. J
Immunol. 2013 Sep 1;191(5):2560-9. doi:
10.4049/jimmunol.1300209. Epub 2013 Aug 5.
Fujiwara
M, Yamamoto H, Miyagi T, Seki T, Tanaka
S, Hide I, Sakai N.
Effects of the chemical chaperone 4-phenylbutylate on the function of the serotonin transporter (SERT) expressed in COS-7 cells.
J Pharmacol Sci.
2013;122(2):71-83. Epub 2013 May 16.
Seki T, Gong L, Williams AJ, Sakai N, Todi SV, Paulson HL.
JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis. J
Biol Chem. 2013 Jun 14;288(24):17145-55. doi:
10.1074/jbc.M113.463406. Epub 2013 Apr 26.
2012年
Yammamoto
H, Tanaka S, Tanaka A, Hide I,
Seki T, Sakai N. Long-term
exposure of RN46A cells expressing serotonin transporter (SERT) to a cAMP
analog up-regulates SERT activity and is accompanied by neural differentiation
of the cells. J
Pharmacol Sci. 2013;121(1):25-38. Epub 2012 Dec 26.
Dohi, E., Tanaka, S., Seki, T., Miyagi, T., Hide, I., Takahashi, T., Matsumoto,
M. and Sakai, N.
Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal
cell survival. Neurochem. Int. 60
(2012) 431-442
Seki, T., Yoshino, K., Tanaka, S., Dohi, E., Onji, T., Yamamoto, K., Hide,
I., Paulson, H.L., Saito, N. and Sakai. N.
Establishment of a novel fluorescence-based method to evaluate chaperone-mediated autophagy in a single neuron
PLoS ONE 7 (2012) e31232
2011年
Sakai, N., Saito, N. and Seki, T.
Molecular pathophysiology of neurodegenerative disease caused by gPKC mutations.
World J. Biol. Psychiatry 12(S1) (2011) 95-98
Shuvaev, A.N., Horiuchi, H., Seki, T., Hanna, G., Irie, T., Iizuka, A., Sakai, N. and Hirai, H.
Mutant PKCg in spinocerebellar ataxia type 14 disrupts synapse elimination
and long-term depression in Purkinje cells in vivo.
J. Neuroscience 31 (2011) 14324-14334
Seki, T., Adachi, Abe-Seki, N., Shimahara, T., Takahashi, H., Yamamoto, K., Saito, N. and Sakai, N.
Elucidation of the molecular mechanism and exploration of novel therapeutics
for spinocerebellar ataxia caused by mutant protein kinase Cγ.
J. Pharmacol. Sci. 116 (2011) 239-247
Shirai, Y. Morioka, S., Sakuma, M., Yoshino, K., Otsuji, C., Sakai, N.,
Kashiwagi, K., Chida. K., Shirakawa, R., Horiuchi, H., Nishigori, C., Ueyama,
T. and Saito, N.
Direct binding of RalA to PKCη and its crucial role in morphological change
during keratinocytes differentiation.
Mol. Biol. Cell 22 (2011) 1340-1352
Harada, K., Hide, I., Seki, T., Tanaka, S., Nakata, Y. and Sakai, N.
Extracellular ATP differentially modulates Toll-like receptor 4-mediated
cell survival and death of microglia.
J.Neurochem. 116 (2011) 1138-1147
2010年
Yanase, Y., Hide, I., Mihara, S., Shirai, Y., Saito, N., Nakata, Y., Hide,
M. and Sakai, N. A critical role for conventional protein kinase C in morphological
changes of rodent mast cells. Immunol. Cell Biol. 89 (2011) 149-159
Seki, T., Takahashi, H., Yamamoto, K., Ogawa, K., Onji, T., Adachi, N., Tanaka, S., Hide, I., Saito, N. and Sakai, N. Congo red, an amyloid-inhibiting compound, alleviates various cellular dysfunction triggered by mutant protein kinase Cγ that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation. J. Pharmacol. Sci. 114 (2010) 206-216
Seki, T., Abe-Seki, N., Kikawada, T., Takahashi, H., Yamamoto, K., Adachi,
N., Tanaka, S., Hide, I., Saito, N. and Sakai, N. The effect of trehalose
on the properties of mutant γPKC, which causes spinocerebellar ataxia type
14 (SCA14), in neuronal cell lines and cultured Purkinje cells. J Biol.
Chem. 285 (2010) 33252-33264
Yamamoto, K., Seki, T., Adachi, N., Takahashi, T. Tanaka, S., Hide, I.,
Saito, N. and Sakai, N. Mutant protein kinase C gamma that causes spinocerebellar
ataxia type 14 (SCA14) is selectively degraded by autophagy. Genes to Cells
15 (2010) 425-437
Toyohira, Y., Ueno, S., Tsutsui, M., Itho, H., Sakai, N., Saito, N., Takahashi,
K. and Yanagihara, N. Stimulatory effects of the soy phytoestrogen genistein
on noradrenalin transporter and serotonin transporter activity. Mol. Nurt.
and Food Res. 54 (2010) 516-24.
2009年
Tanaka, S., Shaikh, IM., Chiocca, EA., Saeki, Y. The Gs-linked receptor
GPR3 inhibits the proliferation of cerebellar granular cells during postnatal
development. PLoS One (2009) s5922
Nobukuni, M., Mochizuki, H., Okada, S., Kameyama, N., Tanaka, A., Yamamoto, H., Amano, T., Seki, T. and Sakai, N. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation. J. Pharmacol. Sci. 111 (2009) 392-404
Hashimoto, K., Amano, T., Kasakura, A., Uhl, GR., Sora, I., Sakai, N.,
Kuzumaki, N., Suzuki, T. and Narita, M. mu-Opioid receptor-independent fashion
of the suppression of sodium currents by mu-opioid analgesics in thalamic
neurons. Neurosci. Lett. 451 (2009) 270-273.
Hashimoto, K., Amano, T., Sakai, N., Suzuki, T. and Narita, M. Cell-dependent
physiological synaptic action of morphine in the rat habenular nucleus:
Morphine both inhibits and facilitates excitatory synaptic transmission.
Neurosci. Lett. 453 (2009) 62-67
Seki, T., Shimahara T., Yamamoto, K., Abe, N., Amano, T., Adachi;, N.,
Takahashi, H., Kashiwagi, K., Saito, N. and Sakai, N. Mutant gPKC found
in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment
of dendrites in primary cultured Purkinje cells. Neurobiol. Dis. 33 (2009)
260-273
2008年
Ohtani, Y., Harada, T., Funasaka, Y., Nakao, K., Takahara, C., Sakai, N.,
Saito, N., Nishigori, C. and Aiba, A. Metabotropic glutamate receptor subtype-1
is essential for in vivo growth of melanoma. Oncogene 27 (2008) 7162-7170
Adachi, N., Kobayashi, T., Takahashi, H., Kawasaki, T., Shirai, Y., Ueyama, T., Matsuda, T., Seki, T., Sakai, N. and Saito, N. Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis. J Biol. Chem. 283 (2008) 19854-19863
Hanaya, R., Kiura, Y., Kurisu, K. Sakai, N., Serikawa, T. and Sasa, M. N-acetyl-l-aspartate activates hippocampal CA3 neurons in rodent slice preparations. Brain Res. Bull. 75 (2008) 663-667
2007年
Seki, T., Takahashi H., Adachi, N., Abe, N., Shimahara, T., Saito, N. and
Sakai, N. Aggregate formation of mutant protein kinase C gamma found in
spinocerebellar ataxia type 14 impairs ubiquitin proteasome system and
induces endoplasmic reticulum stress. Eur. J. Neurosci. 26 (2007) 3126-3140
Hamasaki, T., Tanaka N., Kamei, N., Ishida, O., Yanada, S., Nakanishi, K., Nishida, K., Oishi, Y., Kawamata, S., Sakai, N. and Ochi, M. Magnetically labeled neural progenitor cells, which are localized by magnetic force, promote axon growth in organotypic cocultures. Spine 32 (2007) 2320-2305
Kamei, N, Tanaka , N., Oishi Y., Ishikawa, M., Hamasaki, T., Nishida, K.,
Nakanishi, K., Sakai, N. and Ochi, M. Bone marrow stromal cells promoting
corticospinal axon growth through the release of humoral factors in organotypic
cocultures in neonatal rats. J. Neurosurg Spine 20 (2007) 412-419
Kamei, N., Tanaka, N., Oishi, Y., Hamasaki, T., Nakanishi, K., Sakai, N.
and Ochi, M. BDNF, NT-3, and NGF released from transplanted neural progenitor
cells promote corticospinal axon growth in organotypic cocultures. Spine
32 (2007) 1272-1278.
Okii, N., Amano, T., Seki, T., Matsubayashi, H., Mukai, H., Ono, Y., Kurisu, K. and Sakai, N. Fragmentation of protein kinase N (PKN) in the hydrocephalic rat brain. Acta Histochem.Cytochem. 40 (2007) 113-121
Tanaka, S., Ishii, K., Kasai, K., Yoon, SO., Saeki, Y. Neural expression of G protein-coupled receptors GPR3, GPR6, GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth.J Biol. Chem. 282 (2007) 10506-10515
2006年
Masukawa, K. Sakai, N., Ohmori, S., Shirai, Y. and Saito, N. Spatiotemporal analysis of the molecular interaction between PICK1 and PKC. Acta Histochem.Cytochem. 39 (2006) 173-181
Seki, T., Irie, N., Nakamura, K., Sakaue, H., Ogawa, W., Kasuga, M., Yamamoto,
H., Ohmori, S., Saito, N. and Sakai, N. Fused protein of dPKC activation
loop and PDK1-interacting fragment (dAL-PIF) functions as a pseudosubstrate
and an inhibitory molecule for PDK1 when expressed in cells. Genes to Cells
11 (2006) 1051-1070
Mochizuki, H., Seki, T., Adachi, N., Saito, N., Mishima, H. K. and Sakai,
N. R659S mutation of gamma PKC is susceptible to cell death: Implication
of this mutation/polymorphism in the pathogenesis of retinitis pigmentosa.
Neurochem. Int. 49 (2006) 669-675
Suzuki, T., Hide, I., Matsubara, A., Hama, C., Harada, K.,Miyano, K., Andra, M., Matsubayashi, H., Sakai, N. Kohsaka, S., Inoue, K. and Nakata, Y. Microglial a7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation towards a neuroprotective role. J. Neurosci Res. 83 (2006) 1461-1470
Yamashita, H., Nakamura, T., Takahashi, T. Nagano, Y., Hiji, M. Hirabayashi,
T. Amano, T., Yagi, T. Sakai, N. Kohriyama, T. and Matsumoto, M. Embryonic
stem cell-derived neuron models of Parkinson’s disease exhibit delayed
neuronal death. J. Neurochem. 98 (2006) 45-56
Hiramoto, K., Kawakami, H., Inoue, K., Seki, T., Maruyama, H., Morino,
H., Matsumoto M., Kurisu, K. and Sakai, N. Identification of a new family
of spinocerebellar ataxia type 14 (SCA14) in the Japanese SCA population
by the screening of PRKCG exon 4. Movement Disorders 21 (2006) 1355-1360
2005年
Hirano, K., Seki, T., Sakai, N., Hashimoto, H., Uchida, S. and Yamada ,
S. Effects of continuous administration of paroxetine on ligand binding
site and expression of serotonin transporter protein in mouse brain. Brain
Res 1053 (2005) 154-161
Seki, T., Adachi, N., Ono, Y., Mochizuki, H., Hiramoto, K., Amano, T.,
Matsubayashi, T., Matsumoto, M., Kawakami, H., Saito, N. and Sakai, N.
Mutant protein kinase C gamma found in spinocerebellar ataxia type 14 is
susceptible to aggregation and causes cell death. . J. Biol. Chem., 280
(2005) 29096-29106
Kodama, N., Murata, Y., Asakawa, A., Inui, A., Hayashi, M., Sakai, N. and Nanba, H. Maitake D-fraction enhences antitumor effects and reduced immunosupression by mitomycin-C in tumor-bearing mice. Nutrition 21 (2005) 624-629
Abdel-Raheem, I. T., Hide, I. Yanase, Y., Shigemtoto-Nogami, Y., Sakai,
N., Shirai, Y., Saito, N., Hamada, F.H., El-Mahdy, N. A., Elsisy, A. E-D.
E., Sokar, S. S. and Nakata, Y. Protein kinase C a mediates TNF release
process in RBL-2H3 mast cells. Br. J. Pharmacol. 145 (2005) 415-423
Fukunaga-Takenaka, R., Shirai, Y., Yagi, K., Adachi, N., Sakai, N., Merino,
E., Merida, I. and Saito, N. Importance of chroman ring and tyrosine phosphorylation
in the subtype-specific translocation and activation of diacylglycerol
kinase a by d-a-tocopherol. Genes to Cells 10 (2005) 311-319
Seki, T., Matsubayashi, H., Amano, T., Shirai, Y., Saito, N. and Sakai, N. Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC. Genes to Cells 10 (2005) 225-239
Mochizuki, H., Amano, T., Seki, T. Matsubayashi, H., Mitsuhata, C., Morita, K., Kitayama, S. Dohi, T., Mishima, K. M. and Sakai, N. Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT). Neurochem. Int. 46 (2005) 93-105
2004年
Ueyama, T., Lennartz, M.R., Noda, Y., Kobayashi, T. Shirai, Y., Rikitake, K. Yamasaki, T. Hayashi, S., Sakai, N., Segichi, H., Sawada, M., Sumimoto, H. and Saito, N. Superoxide production at phacosomal cup/phagosime through b1 protein kinase C during DcgR-mediated phagocutosis in micorglia. J. Immunol. 173 (2004) 4582-4589
Sakai, N., Tsubokawa, H., Matsuzaki,, M., Kajimoto, T., Takahashi, E.,
Ren, Y., Ohmori, S.,Shirai, Y., Matsubayashi, H., Chen, J., Duman, R.S.,
Kasai, H. and Saito, N. Propagation of gPKC translocation along the dendrites
of Purkinje cell in gPKC-GFP transgenic mice. Genes to Cells 9 (2004) 945-957
Matsubayashi, H., Inoue, A., Amano, T., Seki, T., Nakata, Y., Sasa, M.
and Sakai, N. Involvement of a7 and a4b2 type postsynaptic nicotinic acetylcholine
receptors in nicotine-induced excitation of dopaminergic neurons in the
substantia nigra: A patch clamp and single-cell PCR study using acutely
dissociated nigral neurons. Mol. Brain Res. 129 (2004) 1-7
Amano, T., Aihua, Z., Matsubayasi, H., Seki, T., Serikawa, T. Sasa, M. and Sakai N. Antiepileptic effects of single and repeated oral administrations of S-312-d, a novel calcium channel antagonist, on tonic convulsions in spontaneously epileptic rats (SER) J. Pharmacol. Sci. 95 (2004) 355-362
Bhattacharjee, A. K., Ueyama, T., Kondoh, T., Hayashi, S., Abouelfetouh,
A., Sakai, N., Saito, N. and Kohmura, E. In vivo transgene expression using
an adenoviral tetracycline-regulated system with neuron-specific enolase
promoter. Biochem. Biophys. Res. Commun. 317 (2004) 1144-1148
Yagi, K. Shirai, Y., Hirai, M., Sakai, N., and Saito, N. Phospholipase
A2 products retain a neuron specific g isoform of PKC on the plasma membrane
through the C1 domain -A molecular mechanism for sustained enzyme
activity. Neurochem. Int. 45 (2004) 39-47
Kajimoto, T., Shirai, Y., Sakai, N., Yamamoto, T., Matsuzaki, H., Kikkawa U., and Saito N. Ceramide-induced apoptosis by translocation, phosphorylation and activation of protein kinase Cdelta at Golgi complex. J. Biol. Chem. 279 (2004) 12668-12676
Seki, T., Matsubayashi, H., Amano, T. Kitada, K. Serikawa, T. Sasa, M.
and Sakai, N. Adenoviral gene transfer of aspartoacylase ameliorates tonic
convulsions of spontaneously epileptic rats. Neurochem. Int. 45 (2004)
171-178
Uchino, M., Sakai, N., Kashiwagi, K., Shirai, Y., Shinohara, Y., Hirose,
K., Iino, M., Yamamura, T. and Saito, N. Isoform-specific phosphorylation
of mGluR5 by PKC blocks Ca2+ oscillation and oscillatory translocation
of Ca2+-dependent PKC. J. Biol. Chem. 279 (2004) 2254-2261 .
Matsubayashi, H., Amano, T., Seki, T., Sasa, M. and Sakai, N. Postsynaptic a4b2 and a7 type nicotinic acetylcholine receptors (nAChRs) contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons. Brain Res. 1005 (2004) 1-8
Matsubayashi, H., Amano, T., Seki, T., Sasa, M. and Sakai, N. Electrophysiological characterization of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra. J. Pharmacol. Sci. 93 (2003) 143-148
Shiwa, T., Amano, T., Matsubayashi, H., Seki, T., Sasa, M. and Sakai, N.
Perospirone, a novel antipsychotic agent, hyperpolarizes rat dorsal raphe
neurons via 5-HT1A receptor. J. Pharmacol. Sci. 93 (2003) 114-117
Amano, T., Matsubayashi, H., Seki, T., Sasa M. and Sakai, N. Repeated administration
of methamphetamine causes hypersensitivity of D2 receptor in rat ventral
tegmental area. Neurosci. Lett. 347 (2003) 89-92
Sakai, K., Hasegawa, C., Okura, M., Morikawa, O., Ueyama, T., Shirai, Y., Sakai, N. and Saito, N. Novel variants of murine serotonin transporter mRNA and the promoter activity of its upstream site Neurosci. Lett. 342 (2003) 175-178
Kiura, Y., Hanaya, R.,Serikawa, T., Kurisu, K., Sakai, N. and Sasa M. Involvement of Ca2+ channels in abnormal excitability of hippocampal CA3 pyramidal cells in Noda epileptic rats. J. Pharmacol. Sci. 91 (2003) 137-144
2002年
Newton, S.S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger L.,
Sakai. N., Chen, J., Neve, R., Nestler, E. J. and Duman R. S. Inhibition
of cAMP response element-binding protein or dynorphin in the nucleus accumbens
produces an antidepressant-like effect. J. Neurosci. 24 (2002) 10883-10890
Irie, N., Sakai, N., Ueyama, T., Uchino, M., Shirai, Y., and Saito, N.
Subtype- and species-specific knockdown of PKC using short interfering
RNA. Biochem. Biophys. Res. Commun.298 (2002) 738-743
Kodama, N., Komuta, K., Sakai, N. and Nanba, H. Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells. Biol. Pharm. Bull. 25 (2002) 1647-1650
Goerke, A., Sakai, N., Gutjahr, E., Schlapkohl, WA, Mushinski, JF., Haller,
H., Kolch, W., Saito, N, and Mischak, H.Induction of apoptosis by
Protein kinase C delta is independent of its kinase activity J. Biol. Chem.
277 (2002) 18037-18045
Seki, T., Matsubayashi, H., Amano, T. Kitada, K. Serikawa, T., Sakai, N.
and Sasa, M Adenoviral gene transfer of aspartoacylase into the tremor
rat, a genetic model of epilepsy, as a trial of gene therapy for inherited
epileptic disorder..Neurosci Lett 328 (2002) 249-252
Sakai, K. Nakamura, M., Sano, A., Sakai, N., and Saito, N. The silencer activity of the novel human serotonin transporter linked polymorphic region. Neurosci. Lett. 327 (2002) 13-16
Nishizaki, T. Nagai, K., Nomura, T. Tada, H. Kanno, T. Tozaki, T. Li, X.
Kondoh, T. Kodama, N. Takahashi, E. Sakai, N. Tanaka. K. and Saito,N. A
new neuromodulator pathway with a glial contribution mediated via A2a adrenergic
receptors. Glia 39 (2002) 133-147
Sakai, N., Thome, J., Newton, SS., Chen, J., Kelz, MB., Steffen, C., Nestler,
EJ. and Duman RS. Inducible and brain region specific CREB transgenic mice
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