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Department of Molecular and Pharmacological Neuroscience, Hiroshima University Institute of Biomedical & Health Sciences

§734-0036 L“‡Œ§L“‡Žs“ì‹æ‰à‚P|‚Q|3
TEL. 082-257-5142

‹ÆÑWNEWS&FAQ

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2022”N



2021”N



2020”N



2019”N




2018”N


  • Nakazono, A., Adachi, N*., Takahashi, H., Seki, T., Hamada, D., Ueyama, T., Sakai, N. and Saito, N.,
    Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCƒÁ in spinocerebellar ataxia type 14
    J. Biol. Chem., 293 (2018) 14758-14774
  • Miyahara, T., Adachi, N., Seki, T., Hide I., , Tanaka, S., Saito, N., Irifune, M. and Sakai, N*.
    Propofol induced diverse and subtype-specific translocation of PKC families,
    J. Pharmacol. Sci. 137 (2018) 20-29.
  • Shirafuji, T*., Ueyama, T., Adachi, N., Yoshino, K. Sotomaru, Y., Uwada, J., Kaneoka, A., Ueda, T., Tanaka, S., Hide, I., Saito, N. and Sakai, N.
    The Role of Cysteine String Protein Alpha (CSPƒ¿) Phosphorylation at Serine 10, and 34, by Protein Kinase CƒÁ for Presynaptic Maintenance.
    J. Neurosci. 38 (2018) 278-290.


2017”N


  • Shirafuji T*, Ueyama T, Tanaka S, Hide I, Saito N and Sakai N.
    Validation of Anti-CSPƒ¿, SNAP25, Tyrosine Hydroxylase, Ubiquitin, Cleaved Caspase 3, and pSer PKC Motif Antibodies for Utilization in Western Blotting.
    Acta Histochem Cytochem. 50 (2017) 177-180.
  • Fujii, H*., Takahashi, T., Mukai, T., Tanak,a S., Hosomi, N., Maruyama, H., Sakai, N., and Matsumoto, M.
    Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer's disease - Hyperphosphorylation and cleavage of 4- and 3-repeat tau.
    J Cereb Blood Flow Metab. 37 (2017) 2441-2457.


2016”N


  • Katarao, K., Murakawa, S., Asano, M., Usuki, N., Yamamoto, H., Shirafuji, T., Tanaka, S., Hide, I. and Sakai, N*..
    The development of screening methods to identify drugs to limit ER stress using wild-type and mutant serotonin transporter.

    Acta Histochem.Cytochem. 49 (2016) 197-206 DOI: 10.1016/j.jtcme.2016.01.006
  • Nakatani, Y., Amano, T., Yamamoto, H., Sakai, N. Tsuji, M. and Takeda, H*.
    Yokukansan enhances the proliferation of B65 neuroblastoma.
    J. Traditional Complement. Med. 7 (2016) 34-44 DOI: 10.1016/j.jtcme.2016.01.006
  • Kamigaki M, Hide I*, Yanase Y, Shiraki H, Harada K, Tanaka Y, Seki T, Shirafuji T, Tanaka S, Hide M, Sakai N.
    The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling.
    Neurochem Int. 2016 Feb;93:82-94. doi: 10.1016/j.neuint.2016.01.003. Epub 2016 Jan 21.
  • Miyagi T, Tanaka S*, Hide I, Shirafuji T, Sakai N.
    The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons.
    PLoS One. 2016 Jan 22;11(1):e0147466. doi: 10.1371/journal.pone.0147466. eCollection 2016.


2015”N


  • Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda KI, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A*.
    The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study.
    Curr Mol Med. 2015;15(3):265-74. doi: 10.2174/1566524015666150330145722
  • Kikuchi N, Irifune M, Shimizu Y, Yoshida K, Morita K, Kanematsu T, Morioka N, Nakata Y, Sakai N*.
    Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility.@
    Psychopharmacology (Berl)
    . 2015 Jan;232(1):39-46. doi: 10.1007/s00213-014-3634-y. Epub 2014 May 31.
  • Takahashi H*, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N.@
    Identification and characterization of PKCƒÁ, a kinase associated with SCA14, as an amyloidogenic protein.
    @
    Hum Mol Genet
    . 2015 Jan 15;24(2):525-39. doi: 10.1093/hmg/ddu472. Epub 2014 Sep 12.


2014”N


  • Tanaka S*, Miyagi T, Dohi E, Seki T, Hide I, Sotomaru Y, Saeki Y, Antonio Chiocca E, Matsumoto M, Sakai N.
    Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli.
    @
    Neurobiol Dis
    . 2014 Aug;68:215-27. doi: 10.1016/j.nbd.2014.04.007. Epub 2014 Apr 24.
  • Shirafuji T, Ueyama T, Yoshino K, Takahashi H, Adachi N, Ago Y, Koda K, Nashida T, Hiramatsu N, Matsuda T, Toda T, Sakai N, Saito N*.@
    The role of Pak-interacting exchange factor-ƒÀ phosphorylation at serines 340 and 583 by PKCƒÁ in dopamine release.
    @
    J Neurosci. 2014 Jul 9;34(28):9268-80. doi: 10.1523/JNEUROSCI.4278-13.2014.
  • Yamamoto K, Seki T*, Yamamoto H, Adachi N, Tanaka S, Hide I, Saito N, Sakai N.@
    Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14.
    @
    Front Physiol
    . 2014 Apr 1;5:126. doi: 10.3389/fphys.2014.00126. eCollection 2014.


2013”N


  • Ogawa K, Seki T, Onji T, Adachi N, Tanaka S, Hide I, Saito N, Sakai N.@ Mutant ƒÁPKC that causes spinocerebellar ataxia type 14 upregulates Hsp70, which protects cells from the mutant's cytotoxicity
    Biochem Biophys Res Commun. 2013 Oct 11;440(1):25-30. doi: 10.1016/j.bbrc.2013.09.013. Epub 2013 Sep 8.
  • Taniguchi T, Tanaka S, Ishii A, Watanabe M, Fujitani N, Sugeo A, Gotoh S, Ohta T, Hiyoshi M, Matsuzaki H, Sakai N, Konishi H.@ A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling
    J Biol Chem. 2013 Oct 11;288(41):29934-42. doi: 10.1074/jbc.M113.492520. Epub 2013 Sep 3.
  • Ueyama T, Son J, Kobayashi T, Hamada T, Nakamura T, Sakaguchi H, Shirafuji T, Saito N.@ Negative charges in the flexible N-terminal domain of Rho GDP-dissociation inhibitors (RhoGDIs) regulate the targeting of the RhoGDI-Rac1 complex to membranes.@
    J Immunol. 2013 Sep 1;191(5):2560-9. doi: 10.4049/jimmunol.1300209. Epub 2013 Aug 5.
  • Fujiwara M, Yamamoto H, Miyagi T, Seki T, Tanaka S, Hide I, Sakai N.@
    Effects of the chemical chaperone 4-phenylbutylate on the function of the serotonin transporter (SERT) expressed in COS-7 cells.
    @
    J Pharmacol Sci
    . 2013;122(2):71-83. Epub 2013 May 16.
  • Seki T, Gong L, Williams AJ, Sakai N, Todi SV, Paulson HL.
    JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis.
    @
    J Biol Chem. 2013 Jun 14;288(24):17145-55. doi: 10.1074/jbc.M113.463406. Epub 2013 Apr 26.


2012”N


  • Yammamoto H, Tanaka S, Tanaka A, Hide I, Seki T, Sakai N.@
    Long-term exposure of RN46A cells expressing serotonin transporter (SERT) to a cAMP analog up-regulates SERT activity and is accompanied by neural differentiation of the cells.
    @
    J Pharmacol Sci. 2013;121(1):25-38. Epub 2012 Dec 26.@
  • Dohi, E., Tanaka, S., Seki, T., Miyagi, T., Hide, I., Takahashi, T., Matsumoto, M. and Sakai, N.
    Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival.

    Neurochem. Int. 60 (2012) 431-442
  • Seki, T., Yoshino, K., Tanaka, S., Dohi, E., Onji, T., Yamamoto, K., Hide, I., Paulson, H.L., Saito, N. and Sakai. N.
    Establishment of a novel fluorescence-based method to evaluate chaperone-mediated autophagy in a single neuron
    PLoS ONE 7 (2012) e31232

2011”N


  • Sakai, N., Saito, N. and Seki, T.
    Molecular pathophysiology of neurodegenerative disease caused by gPKC mutations.
    World J. Biol. Psychiatry 12(S1) (2011) 95-98
  • Shuvaev, A.N., Horiuchi, H., Seki, T., Hanna, G., Irie, T., Iizuka, A., Sakai, N. and Hirai, H.
    Mutant PKCg in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.
    J. Neuroscience 31 (2011) 14324-14334
  • Seki, T., Adachi, Abe-Seki, N., Shimahara, T., Takahashi, H., Yamamoto, K., Saito, N. and Sakai, N.
    Elucidation of the molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant protein kinase CƒÁ.
    J. Pharmacol. Sci. 116 (2011) 239-247
  • Shirai, Y. Morioka, S., Sakuma, M., Yoshino, K., Otsuji, C., Sakai, N., Kashiwagi, K., Chida. K., Shirakawa, R., Horiuchi, H., Nishigori, C., Ueyama, T. and Saito, N.
    Direct binding of RalA to PKCā and its crucial role in morphological change during keratinocytes differentiation.
    Mol. Biol. Cell 22 (2011) 1340-1352
  • Harada, K., Hide, I., Seki, T., Tanaka, S., Nakata, Y. and Sakai, N.
    Extracellular ATP differentially modulates Toll-like receptor 4-mediated cell survival and death of microglia.
    J.Neurochem. 116 (2011) 1138-1147


2010”N


  • Yanase, Y., Hide, I., Mihara, S., Shirai, Y., Saito, N., Nakata, Y., Hide, M. and Sakai, N. A critical role for conventional protein kinase C in morphological changes of rodent mast cells. Immunol. Cell Biol. 89@(2011)@149-159
  • Seki, T., Takahashi, H., Yamamoto, K., Ogawa, K.,  Onji, T., Adachi, N., Tanaka, S., Hide, I., Saito, N. and Sakai, N. Congo red, an amyloid-inhibiting compound, alleviates various cellular dysfunction triggered by mutant protein kinase CƒÁ that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation. J. Pharmacol. Sci. 114 (2010) 206-216
  • Seki, T., Abe-Seki, N., Kikawada, T., Takahashi, H., Yamamoto, K., Adachi, N., Tanaka, S., Hide, I., Saito, N. and Sakai, N. The effect of trehalose on the properties of mutant ƒÁPKC, which causes spinocerebellar ataxia type 14 (SCA14), in neuronal cell lines and cultured Purkinje cells. J Biol. Chem. 285 (2010) 33252-33264
  • Yamamoto, K., Seki, T., Adachi, N., Takahashi, T. Tanaka, S., Hide, I., Saito, N. and Sakai, N. Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy. Genes to Cells 15 (2010) 425-437
  • Toyohira, Y., Ueno, S., Tsutsui, M., Itho, H., Sakai, N., Saito, N., Takahashi, K. and Yanagihara, N. Stimulatory effects of the soy phytoestrogen genistein on noradrenalin transporter and serotonin transporter activity. Mol. Nurt. and Food Res. 54 (2010) 516-24.


2009”N


  • Tanaka, S., Shaikh, IM., Chiocca, EA., Saeki, Y. The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granular cells during postnatal development. PLoS One (2009) s5922
  • Nobukuni, M., Mochizuki, H., Okada, S., Kameyama, N., Tanaka, A., Yamamoto, H., Amano, T., Seki, T. and Sakai, N. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation. J. Pharmacol. Sci. 111 (2009) 392-404
  • Hashimoto, K., Amano, T., Kasakura, A., Uhl, GR., Sora, I., Sakai, N., Kuzumaki, N., Suzuki, T. and Narita, M. mu-Opioid receptor-independent fashion of the suppression of sodium currents by mu-opioid analgesics in thalamic neurons. Neurosci. Lett. 451 (2009)  270-273.
  • Hashimoto, K., Amano, T., Sakai, N., Suzuki, T. and Narita, M. Cell-dependent physiological synaptic action of morphine in the rat habenular nucleus: Morphine both inhibits and facilitates excitatory synaptic transmission. Neurosci. Lett. 453 (2009) 62-67
  • Seki, T., Shimahara T., Yamamoto, K., Abe, N., Amano, T., Adachi;, N., Takahashi, H., Kashiwagi, K., Saito, N. and Sakai, N. Mutant gPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells. Neurobiol. Dis. 33 (2009) 260-273


2008”N


  • Ohtani, Y., Harada, T., Funasaka, Y., Nakao, K., Takahara, C., Sakai, N., Saito, N., Nishigori, C. and Aiba, A. Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma. Oncogene 27 (2008) 7162-7170
  • Adachi, N., Kobayashi, T., Takahashi, H., Kawasaki, T., Shirai, Y., Ueyama, T., Matsuda, T., Seki, T., Sakai, N. and Saito, N. Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis. J Biol. Chem. 283 (2008) 19854-19863
  • Hanaya, R., Kiura, Y., Kurisu, K. Sakai, N., Serikawa, T. and Sasa, M. N-acetyl-l-aspartate activates hippocampal CA3 neurons in rodent slice preparations. Brain Res. Bull. 75 (2008) 663-667


2007”N


  • Seki, T., Takahashi H., Adachi, N., Abe, N., Shimahara, T., Saito, N. and Sakai, N. Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin proteasome system and induces endoplasmic reticulum stress. Eur. J. Neurosci. 26 (2007) 3126-3140
  • Hamasaki, T., Tanaka N., Kamei, N., Ishida, O., Yanada, S., Nakanishi, K., Nishida, K., Oishi, Y., Kawamata, S., Sakai, N. and Ochi, M. Magnetically labeled neural progenitor cells, which are localized by magnetic force, promote axon growth in organotypic cocultures. Spine  32 (2007) 2320-2305
  • Kamei, N, Tanaka , N., Oishi Y., Ishikawa, M., Hamasaki, T., Nishida, K., Nakanishi, K., Sakai, N. and Ochi, M. Bone marrow stromal cells promoting corticospinal axon growth through the release of humoral factors in organotypic cocultures in neonatal rats. J. Neurosurg Spine 20 (2007) 412-419
  • Kamei, N., Tanaka, N., Oishi, Y., Hamasaki, T., Nakanishi, K., Sakai, N. and Ochi, M. BDNF, NT-3, and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic cocultures. Spine 32 (2007) 1272-1278.
  • Okii, N., Amano, T., Seki, T., Matsubayashi, H., Mukai, H., Ono, Y., Kurisu, K. and Sakai, N. Fragmentation of protein kinase N (PKN) in the hydrocephalic rat brain. Acta Histochem.Cytochem. 40 (2007) 113-121
  • Tanaka, S., Ishii, K., Kasai, K., Yoon, SO., Saeki, Y. Neural expression of G protein-coupled receptors GPR3, GPR6, GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth.J Biol. Chem. 282 (2007) 10506-10515


2006”N


  • Masukawa, K. Sakai, N., Ohmori, S., Shirai, Y. and Saito, N. Spatiotemporal analysis of the molecular interaction between  PICK1 and PKC. Acta Histochem.Cytochem. 39 (2006) 173-181
  • Seki, T., Irie, N., Nakamura, K., Sakaue, H., Ogawa, W., Kasuga, M., Yamamoto, H., Ohmori, S., Saito, N. and Sakai, N. Fused protein of dPKC activation loop and PDK1-interacting fragment (dAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells. Genes to Cells 11 (2006) 1051-1070
  • Mochizuki, H., Seki, T., Adachi, N., Saito, N., Mishima, H. K. and Sakai, N.  R659S mutation of gamma PKC is susceptible to cell death: Implication of this mutation/polymorphism in the pathogenesis of retinitis pigmentosa. Neurochem. Int. 49 (2006) 669-675
  • Suzuki, T., Hide, I., Matsubara, A., Hama, C., Harada, K.,Miyano, K., Andra, M., Matsubayashi, H., Sakai, N. Kohsaka, S., Inoue, K. and Nakata, Y. Microglial  a7 nicotinic acetylcholine@receptors drive a phospholipase C/IP3 pathway and modulate the cell activation towards a neuroprotective role. J. Neurosci Res. 83 (2006) 1461-1470
  • Yamashita, H., Nakamura, T., Takahashi, T. Nagano, Y., Hiji, M. Hirabayashi, T. Amano, T., Yagi, T. Sakai, N. Kohriyama, T. and Matsumoto, M. Embryonic stem cell-derived neuron models of Parkinsonfs disease exhibit delayed neuronal death. J. Neurochem. 98 (2006) 45-56
  • Hiramoto, K., Kawakami, H., Inoue, K., Seki, T., Maruyama, H., Morino, H., Matsumoto M., Kurisu, K. and Sakai, N. Identification of a new family of spinocerebellar ataxia type 14 (SCA14) in the Japanese SCA population by the screening of PRKCG exon 4. Movement Disorders 21 (2006) 1355-1360


2005”N


  • Hirano, K., Seki, T., Sakai, N., Hashimoto, H., Uchida, S. and Yamada , S. Effects of continuous administration of paroxetine on ligand binding site and expression of serotonin transporter protein in mouse brain. Brain Res 1053 (2005) 154-161
  • Seki, T., Adachi, N., Ono, Y., Mochizuki, H., Hiramoto, K., Amano, T., Matsubayashi, T., Matsumoto, M., Kawakami, H., Saito, N. and Sakai, N. Mutant protein kinase C gamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death. . J. Biol. Chem.,   280 (2005) 29096-29106
  • Kodama, N., Murata, Y., Asakawa, A., Inui, A., Hayashi, M., Sakai, N. and Nanba, H. Maitake D-fraction enhences antitumor effects and reduced immunosupression by mitomycin-C in tumor-bearing mice. Nutrition 21 (2005) 624-629
  • Abdel-Raheem, I. T., Hide, I. Yanase, Y., Shigemtoto-Nogami, Y., Sakai, N., Shirai, Y., Saito, N., Hamada, F.H., El-Mahdy, N. A., Elsisy, A. E-D. E., Sokar, S. S. and Nakata, Y. Protein kinase C a mediates TNF release process in RBL-2H3 mast cells. Br. J. Pharmacol. 145 (2005) 415-423
  • Fukunaga-Takenaka, R., Shirai, Y., Yagi, K., Adachi, N., Sakai, N., Merino, E., Merida, I. and Saito, N. Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase a by d-a-tocopherol. Genes to Cells 10 (2005) 311-319
  • Seki, T., Matsubayashi, H., Amano, T., Shirai, Y., Saito, N. and Sakai, N. Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC. Genes to Cells 10 (2005) 225-239
  • Mochizuki, H., Amano, T., Seki, T. Matsubayashi, H., Mitsuhata, C., Morita, K., Kitayama, S. Dohi, T., Mishima, K. M. and Sakai, N. Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT).  Neurochem. Int. 46 (2005) 93-105


2004”N


  • Ueyama, T., Lennartz, M.R., Noda, Y., Kobayashi, T. Shirai, Y., Rikitake, K. Yamasaki, T. Hayashi, S., Sakai, N., Segichi, H., Sawada, M., Sumimoto, H. and Saito, N. Superoxide production at phacosomal cup/phagosime through b1 protein kinase C during DcgR-mediated phagocutosis in micorglia. J. Immunol. 173 (2004) 4582-4589
  • Sakai, N., Tsubokawa, H., Matsuzaki,, M., Kajimoto, T., Takahashi, E., Ren, Y., Ohmori, S.,Shirai, Y., Matsubayashi, H., Chen, J., Duman, R.S., Kasai, H. and Saito, N. Propagation of gPKC translocation along the dendrites of Purkinje cell in gPKC-GFP transgenic mice. Genes to Cells 9@(2004) 945-957
  • Matsubayashi, H., Inoue, A., Amano, T., Seki, T., Nakata, Y., Sasa, M. and Sakai, N. Involvement of a7 and a4b2 type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: A patch clamp and single-cell PCR study using acutely dissociated nigral neurons. Mol. Brain Res. 129 (2004) 1-7
  • Amano, T., Aihua, Z., Matsubayasi, H., Seki, T., Serikawa, T. Sasa, M. and Sakai N. Antiepileptic effects of single and repeated oral administrations of S-312-d, a novel calcium channel antagonist, on tonic convulsions in spontaneously epileptic rats (SER) J. Pharmacol. Sci. 95 (2004) 355-362
  • Bhattacharjee, A. K., Ueyama, T., Kondoh, T., Hayashi, S., Abouelfetouh, A., Sakai, N., Saito, N. and Kohmura, E. In vivo transgene expression using an adenoviral tetracycline-regulated system with neuron-specific enolase promoter. Biochem. Biophys. Res. Commun. 317 (2004) 1144-1148
  • Yagi, K. Shirai, Y., Hirai, M., Sakai, N., and Saito, N. Phospholipase A2 products retain a neuron specific g isoform of PKC on the plasma membrane through the C1 domain  -A molecular mechanism for sustained enzyme activity. Neurochem. Int. 45 (2004) 39-47
  • Kajimoto, T., Shirai, Y., Sakai, N., Yamamoto, T., Matsuzaki, H., Kikkawa U., and Saito N. Ceramide-induced apoptosis by translocation, phosphorylation and@activation of protein kinase Cdelta at Golgi complex. J. Biol. Chem. 279 (2004) 12668-12676
  • Seki, T., Matsubayashi, H., Amano, T. Kitada, K. Serikawa, T. Sasa, M. and Sakai, N. Adenoviral gene transfer of aspartoacylase ameliorates tonic convulsions of spontaneously epileptic rats. Neurochem. Int. 45 (2004) 171-178
  • Uchino, M., Sakai, N., Kashiwagi, K., Shirai, Y., Shinohara, Y., Hirose, K., Iino, M., Yamamura, T. and Saito, N. Isoform-specific phosphorylation of mGluR5 by PKC blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC. J. Biol. Chem. 279 (2004) 2254-2261 .
  • Matsubayashi, H., Amano, T., Seki, T., Sasa, M. and Sakai, N. Postsynaptic a4b2 and a7 type nicotinic acetylcholine receptors (nAChRs) contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons. Brain Res. 1005 (2004) 1-8
  • MMehlmann, LM., Saeki, Y., Tanaka, S., Brennan, TJ., Evsikov, AV., Pendola, FL., Knowles, BB., Eppig, JJ., Jaffe, LA. The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science (2004) 1947-50


2003”N


  • Matsubayashi, H., Amano, T., Seki, T., Sasa, M. and Sakai, N. Electrophysiological characterization of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra. J. Pharmacol. Sci. 93 (2003) 143-148
  • Shiwa, T., Amano, T., Matsubayashi, H., Seki, T., Sasa, M. and Sakai, N. Perospirone, a novel antipsychotic agent, hyperpolarizes rat dorsal raphe neurons via 5-HT1A receptor. J. Pharmacol. Sci. 93 (2003) 114-117
  • Amano, T., Matsubayashi, H., Seki, T., Sasa M. and Sakai, N. Repeated administration of methamphetamine causes hypersensitivity of D2 receptor in rat ventral tegmental area. Neurosci. Lett. @347 (2003) 89-92
  • Sakai, K., Hasegawa, C., Okura, M., Morikawa, O., Ueyama, T., Shirai, Y., Sakai, N. and Saito, N. Novel variants of murine serotonin transporter mRNA and the promoter activity of its upstream site Neurosci. Lett. 342 (2003) 175-178
  • Kiura, Y., Hanaya, R.,Serikawa, T.,  Kurisu, K., Sakai, N. and Sasa M. Involvement of Ca2+ channels in abnormal excitability of hippocampal CA3 pyramidal cells in Noda epileptic rats. J. Pharmacol. Sci. 91 (2003) 137-144


2002”N


  • Newton, S.S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger L., Sakai. N., Chen, J., Neve, R., Nestler, E. J. and Duman R. S. Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J. Neurosci. 24 (2002) 10883-10890
  • Irie, N., Sakai, N., Ueyama, T., Uchino, M., Shirai, Y., and Saito, N. Subtype- and species-specific knockdown of PKC using short interfering RNA. Biochem. Biophys. Res. Commun.298 (2002) 738-743
  • Kodama, N., Komuta, K., Sakai, N. and Nanba, H. Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells. Biol. Pharm. Bull. 25 (2002) 1647-1650
  • Goerke, A., Sakai, N., Gutjahr, E., Schlapkohl, WA, Mushinski, JF., Haller, H., Kolch,  W., Saito, N, and Mischak, H.Induction of apoptosis by Protein kinase C delta is independent of its kinase activity J. Biol. Chem. 277 (2002) 18037-18045
  • Seki, T., Matsubayashi, H., Amano, T. Kitada, K. Serikawa, T., Sakai, N. and Sasa, M Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder..Neurosci Lett  328  (2002) 249-252
  • Sakai, K. Nakamura, M., Sano, A., Sakai, N., and Saito, N. The silencer activity of the novel human serotonin transporter linked polymorphic region. Neurosci. Lett. 327 (2002) 13-16
  • Nishizaki, T. Nagai, K., Nomura, T. Tada, H. Kanno, T. Tozaki, T. Li, X. Kondoh, T. Kodama, N. Takahashi, E. Sakai, N. Tanaka. K. and Saito,N. A new neuromodulator pathway with a glial contribution mediated via A2a adrenergic receptors. Glia  39 (2002) 133-147
  • Sakai, N., Thome, J., Newton, SS., Chen, J., Kelz, MB., Steffen, C., Nestler, EJ. and Duman RS. Inducible and brain region specific CREB transgenic mice Mol. Pharmacol. 61 (2002)  1453-1464
  • Kashiwagi, K., Shirai, Y., Kuriyama, M., Sakai, N. and Saito, N.  Importance of C1B domain for lipid messenger-induced targeting of PKC. J. Biol. Chem. 277 (2002) 18037-18045



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